ATS 2009 · San Diego
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| Abstract Number: 561 |
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| Contact/Presenting Author: Avni Y. Joshi | |
| Department/Institution: Internal Medicine, Mayo Clinic | |
| Address: 200, First St. SW | |
| City/State/Zip/Country: Rochester, MN, 55905 | |
| Phone: 01-507-284-2511 Fax: 01-507-284-0902 E-mail: joshi.avni@mayo.edu | |
| ATS member: No Student or in training: Yes | |
| Funding Source: None. | |
Abstract Category: 14.03 - Pediatric Asthma |
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| Presentation format: Either Poster or Oral | |
| Preview Disclosure | |
| Travel Award: Yes | |
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Publication of email address:
Yes, joshi.avni@mayo.edu I confirm that all authors listed on this abstract have knowledge of the abstract submission: Yes |
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Title: Flu Vaccination in Asthmatics: Does It Work? A. Y. Joshi, MD1, V. N. Iyer, MD,MPH1, M. F. Hartz, MD1, G. W. Volcheck, MD,Ph.D1, A. M. Patel, MD1 and J. T. Li, MD,Ph.D1. 1Mayo Clinic College of Medicine, Rochester, MN. INTRODUCTION: Influenza is known to be associated with asthma exacerbation but the effectiveness of the trivalent inactivated flu vaccine (TIV) in asthmatics is unknown. METHODS: We conducted a cohort study of all pediatric subjects( 6 months to 18 years age) who were evaluated at Mayo Clinic, Rochester, MN, USA who had laboratory confirmed influenza during each flu season from 1999-2006 to evaluate the efficacy of TIV. A case control analysis was performed with the cases and the controls being the subjects with asthma who did and did not required hospitalization with the influenza illness respectively. RESULTS: There were 236 subjects with laboratory confirmed influenza from 1996-2006. In assessing the effectiveness of the TIV for preventing hospitalization with influenza in all subjects, there was an overall trend towards higher rates of hospitalization in subjects who got the TIV as compared to the ones who did not get the TIV( OR:2.97, CI: 1.3,6.7).Using Cochran-Mantel-Haenszel (CMH) test for Asthma status stratification, there was a significant association between hospitalization in asthmatic subjects and TIV (P=0.006). In the asthmatic subset: There was no association between ER visit and receiving the TIV ,severity of asthma and the risk of hospitalization or the hospital length of stay and receiving the TIV. In assessing access to medical care, there was no association between hospitalizations and health care insurance plans (Odds ratio:0.3, P= 0.13) CONCLUSION: 1) TIV did not provide any protection against hospitalization in pediatric subjects' esp. children with asthma. On the contrary, we found a 3- fold increased risk of hospitalization in subjects who did get the TIV vaccine.This may be a reflection not only of the vaccine effectiveness but also the population of children who are more likely to get the vaccine. 2) More studies are needed to assess not only the immunogenicity but also efficacy of different influenza vaccines in asthmatic subjects. |
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